Severity of group B streptococcal arthritis in selected strains of laboratory mice.
نویسندگان
چکیده
The susceptibilities of C3H/HeN, BALB/c, and C57BL/6N mouse strains to group B streptococci (GBS) infection were evaluated. C3H/HeN mice developed severe polyarthitis; mild lesions and no lesions were observed in BALB/c and C57BL/6N mice, respectively. A correlation between the severity of arthritis, the number of GBS in the joints, and local interleukin-6 and interleukin-1beta production was evident.
منابع مشابه
Severity of group B streptococcal arthritis is correlated with beta-hemolysin expression.
Septic arthritis is a clinical manifestation of group B streptococcal (GBS) infection in neonates and adults. To examine the potential role of GBS beta-hemolysin in joint injury, mice were infected with 2 wild-type strains or with nonhemolytic (NH) or hyperhemolytic (HH) variants derived by transposon mutagenesis. Compared with mice infected with the parent strains, mice infected with the NH mu...
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متن کاملجستجوی آنتی ژن پلی ساکاریدی استر پتوکک گروه آ در مایع مفصلی بیماران مبتلا به آرتریت
Background: Determining the etiologic agents of septic arthritis is very important. The aim of the present study was to determine group A streptococcal polysaccharide antigens in synovial fluid of patients with arthritis. Methods: A cross sectional study was conducted upon 52 cases with acute mono arthritis in Hazrat-e-Rasool Akram hospital in Tehran, Iran (2010-2012).Gram staining, ...
متن کاملIL-4 Deficiency Decreases Mortality but Increases Severity of Arthritis in Experimental Group B Streptococcus Infection
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ورودعنوان ژورنال:
- Infection and immunity
دوره 69 1 شماره
صفحات -
تاریخ انتشار 2001